Valproate semisodium

From Wikipedia, the free encyclopedia

(Redirected from Divalproex sodium)
Jump to: navigation, search
Main article: Valproic acid

Valproate semisodium (INN) or divalproex sodium (USAN) consists of a compound of sodium valproate and valproic acid in a 1:1 molar relationship in an enteric coated form. It is used in the UK and U.S. for the treatment of the manic episodes of bipolar disorder, and increasingly taken long-term for prevention of both manic and depressive phases of bipolar disorder, especially the rapid-cycling variant. It is also used in the US for the treatment of epilepsy, chronic pain associated with neuropathy, and migraine headaches. Its chemical name is sodium hydrogen bis(2-propylpentanoate). The extended release formulation allows for a single daily dose.

In the UK semisodium valproate has been sold for a few years as the proprietary drug Depakote and marketed for psychiatric conditions only. It is about five times the price of sodium valproate, which has been marketed for around 30 years as Epilim by the same company for epilepsy and is also available from other manufacturers as a generic product.

People who take this drug can experience a variety of side effects, some of which may or may not require immediate medical attention. Especially dangerous side effects include vomiting, loss of appetite, fever, or dark urine. These suggest a possibility of liver damage. People taking this drug should also call their doctor if they experience other serious side effects. Some serious side effects are unusual bleeding (especially in the urine), hallucinations, and extreme drowsiness.

The patent held by Abbott Laboratories will expire on January 29, 2008. .[1]

Tablets  This pharmacology-related article is a stub. You can help Wikipedia by expanding it.
v • d • e
Anticonvulsants (N03)
Barbiturates Barbexaclone, Metharbital, Methylphenobarbital, Pentobarbital, Phenobarbital, Primidone
Hydantoins Ethotoin, Fosphenytoin, Mephenytoin, Phenytoin
Oxazolidinediones Ethadione, Paramethadione, Trimethadione
Succinimides Ethosuximide, Mesuximide, Phensuximide
Benzodiazepines Clobazam, Clonazepam, Clorazepate, Diazepam, Lorazepam, Midazolam, Nitrazepam, Temazepam
Carboxamides Carbamazepine, Oxcarbazepine, Rufinamide
Fatty acid derivatives Valpromide, Valnoctamide
Carboxylic acids Valproic acid (Sodium valproate & Valproate semisodium), Tiagabine
Others GABA analogs: Gabapentin, Pregabalin, Progabide, Vigabatrin -- Monosaccharides: Topiramate -- Aromatic allylic alcohols: Stiripentol -- Ureas: Phenacemide, Pheneturide -- Phenyltriazines: Lamotrigine

Carbamates: Emylcamate, Felbamate, Meprobamate -- Pyrrolidines: Brivaracetam, Levetiracetam, Nefiracetam, Seletracetam

Sulfa drugs: Acetazolamide, Ethoxzolamide, Sultiame, Zonisamide -- Propionates: Beclamide -- Aldehydes: Paraldehyde -- Bromides: Potassium bromide, Sodium bromide
Retrieved from "http://en.wikipedia.org/wiki/Valproate_semisodium"
Advanced Search
Included Web Search Engines


Safe Search

close

Top Matching Results

Occasionally Search.com will highlight specialized results that are based on the context of your query. Examples of specialized results include specific links to news, images, or video.

Top Matching Results may highlight information from other Search.com pages, content from the CNET Network of sites, or third party content. The listings are based purely on relevance. Search.com does not receive payment for listings in this section but our partners that provide this data may get paid for listing these products.

Sponsored Links

This section contains paid listings which have been purchased by companies that want to have their sites appear for specific search terms and related content. These listings are administered, sorted and maintained by a third party and are not endorsed by Search.com.

Search Results

Search.com sends your search query to several search engines at one time and integrates the results into one list which has been sorted by relevance using Search.com's proprietary algorithm. You can customize the list of search engines included in your metasearch from the preferences.

The search engines that are used in your metasearch may allow companies to pay to have their Web sites included within the results. To view the Paid Inclusion policy for a specific search engine, please visit their Web site. Search.com does not accept payment or share revenue with any search engine partner for listings in this section.