Trimethadione

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Trimethadione
Systematic (IUPAC) name
3,5,5-trimethyl-1,3-oxazolidine-2,4-dione
Identifiers
CAS number 127-48-0
ATC code N03AC02
PubChem 5576
DrugBank APRD00315
Chemical data
Formula C6H9NO3 
Mol. mass 143.141
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

X
Legal status

℞ Prescription only
Routes  ?

Trimethadione is an oxazolidinedione anticonvulsant. It is used to treat epileptic conditions that are resistant to other treatments; recent studies by Doctor Jianxin Bao, Ph.D., at Washington University in Saint Louis's Central Institute For The Deaf's Center For Presbyacusis and Aging suggest that trimethadione, along with other oxazolidinedione anticonvulsant medications may be useful in treating sensorineural hearing loss cases like those of Iraq war veterans- if the drug's side effects, like dizziness, can be lessened by modifying the drug so it does not cross into the brain itself.

If administered during pregnancy, fetal trimethadione syndrome may result. The fetal loss rate while using trimethadione has been reported to be as high as 87%.[1]

Pills  This pharmacology-related article is a stub. You can help Wikipedia by expanding it.


v • d • e
Anticonvulsants (N03)

Barbiturates: Barbexaclone, Metharbital, Methylphenobarbital, Phenobarbital, Primidone

Hydantoins: Ethotoin, Fosphenytoin, Mephenytoin, Phenytoin

Oxazolidinediones: Ethadione, Paramethadione, Trimethadione

Succinimides: Ethosuximide, Mesuximide, Phensuximide

Benzodiazepines: Clobazam, Clonazepam, Clorazepate, Diazepam, Lorazepam, Midazolam, Nitrazepam, Temazepam

Carboxamides: Carbamazepine, Oxcarbazepine, Rufinamide Fatty acid derivatives: Valpromide, Valnoctamide

Carboxylic acids: Valproic acid (Sodium valproate & Valproate semisodium), Tiagabine -- GABA analogs: Gabapentin, Pregabalin, Progabide, Vigabatrin

Others:- Monosaccharides: Topiramate -- Aromatic allylic alcohols: Stiripentol -- Ureas: Phenacemide, Pheneturide -- Phenyltriazines: Lamotrigine

Carbamates: Emylcamate, Felbamate, Meprobamate -- Pyrrolidines: Brivaracetam, Levetiracetam, Nefiracetam, Seletracetam

Sulfa drugs: Acetazolamide, Ethoxzolamide, Sultiame, Zonisamide -- Propionates: Beclamide -- Aldehydes: Paraldehyde -- Bromides: Potassium bromide, Sodium bromide

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