Thiothixene

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Thiothixene
Systematic (IUPAC) name
(Z)-N,N-dimethyl-9-
[3-(4-methylpiperazin-1-yl)propylidene]-
thioxanthene-2-sulfonamide
Identifiers
CAS number 5591-45-7
ATC code N05AF04
PubChem 5454
DrugBank none
Chemical data
Formula C23H29N3O2S2 
Mol. mass 443.627
Pharmacokinetic data
Bioavailability  ?
Metabolism Hepatic
Half life 10-20 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?
Legal status

?
Routes oral

Thiothixene (sold as Navane) is a thioxanthene drug used as a typical antipsychotic medication. It is a thioxanthene derivative and is the cis isomer of N,Ndimethyl- 9-[3-(4-methyl-1-piperazinyl)-propylidene] thioxanthene-2-sulfonamide.

Although widely used in the treatment of schizophrenia for several decades, thiothixene is seldom used today in favor of atypical antipsychotics such as risperidone.


v • d • e
Psycholeptics: antipsychotics (N05A)
Phenothiazine typical antipsychotics Chlorpromazine • Fluphenazine • Mesoridazine • Perphenazine • Prochlorperazine • Promazine • Thioridazine/Sulforidazine • Trifluoperazine
Other typical antipsychotics Indoles (Molindone) • Butyrophenones (Azaperone, Benperidol, Droperidol, Haloperidol, Trifluperidol) • Thioxanthenes (Flupentixol, Chlorprothixene, Thiothixene, Zuclopenthixol) • diphenylbutylpiperidines (Fluspirilene, Penfluridol, Pimozide) • other (Loxapine)
Atypical antipsychotics Butyrophenones (Melperone) • Indoles (Sertindole, Ziprasidone) • Benzamides (Sulpiride, Remoxipride, Amisulpride) • diazepines/oxazepines/thiazepines (Clozapine, Olanzapine, Quetiapine) • other (Aripiprazole, Risperidone, Paliperidone, Asenapine, Iloperidone, Zotepine)


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