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Sertoli cell
Germinal epithelium of the testicle. 1: basal lamina 2: spermatogonia 3: spermatocyte 1st order 4: spermatocyte 2nd order 5: spermatid 6: mature spermatid 7: Sertoli cell 8: tight junction (blood testis barrier)
Histological section through testicular parenchyma of a boar. 1 Lumen of Tubulus seminiferus contortus 2 spermatids 3 spermatocytes 4 spermatogonia 5 Sertoli cell 6 Myofibroblasts 7 Leydig cells 8 capillaries
Gray's	subject #258 1243
MeSH	Sertoli+Cells

A Sertoli cell (a kind of sustentacular cell) is a 'nurse' cell of the testes which is part of a seminiferous tubule.

It is activated by follicle-stimulating hormone, and has FSH-receptor on its membranes.

Contents 1 Functions 1.1 Secretory 1.2 Structural 1.3 Other functions 2 Production of Sertoli cells 3 Nomenclature 4 Histology 5 Pathology 6 Additional images 7 References 8 See also 9 External links

Its main function is to nurture the developing sperm cells through the stages of spermatogenesis. Because of this, it has also been called the "mother cell." It provides both secretory and structural support.

Sertoli cells secrete the following substances:

• anti-Müllerian hormone (AMH) - secreted during the early stages of fetal life.

• inhibin and activins - secreted after puberty, and work together to regulate FSH secretion

• androgen binding protein - facilitate spermatogenesis and sperm maturation

• glial cell line-derived neurotrophic factor (GDNF) - has been demonstrated to function in promoting undifferentiating spermatogonia, which ensures stem cell self-renewal during the perinatal period.

• the Ets related molecule (ERM transcription factor) - needed for maintenance of the spermatogonial stem cell in the adult testis.

• transferrin^[1]

The junctions of Sertoli cells form the blood-testis barrier, a structure that partitions the interstitial blood compartment of the testis from the adluminal compartment of the seminiferous tubules. Sertoli cells control the entry and exit of nutrients, hormones and other chemicals into the tubules of the testis as well as make the adluminal compartment an immune-privileged site.

The cell is also responsible for establishing and maintaining the spermatogonial stem cell niche, which ensures the renewal of stem cells and the differentiation of spermatogonia into mature germ cells that progress stepwise through the long process of spermatogenesis, ending in the release of spermatozoa. Sertoli cells bind to spermatogonial cells via N-cadherins and galctosyltransferase (via carbohydrate residues).

During the Maturation phase of spermiogenesis, the Sertoli cells consume the unneeded portions of the spermatozoa.

Once fully differentiated, the Sertoli cell is unable to proliferate. Therefore, once spermatogenesis has begun, no more Sertoli cells are created.

Recently however, some scientists have found a way to grow these cells outside of the body. This gives rise to the possibility of repairing some defects that cause male infertility.

Sertoli cells are called so because of their eponym Enrico Sertoli, an Italian physiologist who discovered them while studying medicine in the University of Pavia, Italy. ^[2]

He published a description of this cell in 1865. The cell was discovered by Sertoli with a Belthle microscope purchased in 1862, which he used while studying medicine.

In the 1865 publication, his first description used the terms "tree-like cell" or "stringy cell" and most importantly he referred to these "mother cells." It was other scientists who used Enrico's family name, Sertoli, to label these cell in publications, starting in 1888. As of 2006, two textbooks that are devoted specifically to the Sertoli cell have been published.

On slides, using standard staining, it can be easy to confuse the Sertoli cells with the other cells of the germinal epithelium. The most distinctive of the Sertoli cells is the dark nucleolus.^[3]

Sertoli-Leydig cell tumour are part of the sex cord-stromal tumour group of ovarian neoplasms.

Transverse section of a tubule of the testis of a rat. X 250.

1. ^ Xiong X, Wang A, Liu G, Liu H, Wang C, Xia T, Chen X, Yang K (2006). "Effects of p,p'-dichlorodiphenyldichloroethylene on the expressions of transferrin and androgen-binding protein in rat Sertoli cells.". Environ Res 101 (3): 334-9. PMID 16380112. 
2. ^ synd/518 at Who Named It
3. ^ http://www.cvm.okstate.edu/instruction/mm_curr/histology/MR/HiMRP4.htm

• Sertoli cell only syndrome

• Reproductive Physiology at ufp.pt
• Histology at BU 17805loa
• Histology at BU 17806loa
• Histology at USC rep/c_74
• Histology at OU 29_04

v • d • e Male reproductive system
Scrotum	layers (skin, Dartos, External spermatic fascia, Cremaster/Cremasteric fascia, Internal spermatic fascia) • Perineal raphe • Spermatic cord
Testes	layers (Tunica vaginalis, Tunica albuginea) • Appendix • Mediastinum • Lobules • Septa • Leydig cell • Sertoli cell • Blood-testis barrier
Spermatogenesis	Spermatogonium • Spermatocytogenesis • Spermatocyte • Spermatidogenesis • Spermatid • Spermiogenesis • Spermatozoon
seminal tract	Seminiferous tubules (Tubuli seminiferi recti, Rete testis, Efferent ducts) • Epididymis  (Appendix) • Vas deferens (Ampulla) • Ejaculatory duct
urinary tract	Internal urethral orifice • Urethra (Prostatic, Intermediate, Spongy, Navicular fossa) • External urethral orifice
accessory glands	Seminal vesicles  (Excretory duct of seminal gland) • Prostate  (Urethral crest/Seminal colliculus/Prostatic utricle/Ejaculatory duct, Prostatic sinus/Prostatic ducts) • Bulbourethral glands
Penis	root (Crus, Bulb, Fundiform ligament, Suspensory ligament) • body (Corpus cavernosum, Corpus spongiosum) • glans (Foreskin, Frenulum, Corona) • fascia (superficial/subcutaneous, deep/Buck's) • Tunica albuginea - Septum of the penis