Related Directory Categories
- Proteins and Enzymes (211)
- Proteomics (138)
- Products and Services (51)
- Research Groups (50)
- Protein Analysis (44)
- Structure (42)
- Proteins (32)
- Contract Services (20)
- Enzymes (19)
- Associations (16)
Sources
open directory project
Help build the largest human-edited directory on the web.
Submit a site - Become an editor
Wikipedia. Licensed under the GNU Free Documentation License.
Are you an expert in this subject? Join the discussion and share your knowledge at Wikipedia.org.
SMAD (protein)
From Wikipedia, the free encyclopedia
SMAD's are a class of proteins that modulate the activity of transforming growth factor beta ligands.
The SMAD's form complexes, often with other SMAD's, enter the nucleus and serve as transcription factors.
Contents |
There are three classes of SMAD:
- 1) receptor regulated SMAD (R-SMAD) which include SMAD1, SMAD2, SMAD3, SMAD5 and SMAD9
- 2) the coSMAD SMAD4
- 3) inhibitory SMAD (I-SMAD) which include SMAD6 and SMAD7.
The SMAD proteins are homologs of both the drosophila protein, mothers against decapentaplegic (MAD) and the C. elegans protein SMA. The name is a combination of the two.
During Drosophila research, it was found that a mutation in the gene, MAD, in the mother, repressed the gene, decapentaplegic, in the embryo. The phrase "Mothers against" was added since mothers often form organizations opposing various issues eg. Mothers Against Drunk Driving or (MADD).
| This article needs additional citations for verification. Please help improve this article by adding reliable references. Unsourced material may be challenged and removed. (November 2006) |
|
|
|
|---|---|
| STAT | STAT1 - STAT2 - STAT3 - STAT4 - STAT5 - STAT6 |
| Interferon regulatory factors | IRF1 - IRF2 - IRF3 - IRF6 |
| Growth factor receptor-bound protein | GRB2 - GRB7 - GRB10 |
| other | 14-3-3 - Caveolin - Cortactin - Death Inducing Signaling Complex - Paxillin - Myd88 - PIAS - SMAD - SOCS - TRAF |
|
|
|
|---|---|
| TGF beta superfamily of ligands | TGF beta family (TGF-β1, TGF-β2, TGF-β3) Bone morphogenetic proteins (BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMP8a, BMP8b, BMP10 , BMP15) Growth differentiation factors (GDF1, GDF2, GDF3, GDF5, GDF6, GDF7, Myostatin/GDF8, GDF9, GDF10, GDF11, GDF15) Other (Activin A and B/Inhibin A and B, Anti-müllerian hormone, Nodal) |
| TGF beta receptors | TGFBR1: Activin type 1 receptors (ACVR1, ACVR1B, ACVR1C) - ACVRL1 - BMPR1 (BMPR1A - BMPR1B) TGFBR2: Activin type 2 receptors (ACVR2A, ACVR2B) - AMHR2 - BMPR2 TGFBR3: betaglycan |
| Transducers/SMAD | R-SMAD (SMAD1, SMAD2, SMAD3, SMAD5, SMAD9) - I-SMAD (SMAD6, SMAD7) - SMAD4 |
| Ligand Inhibitors | Cerberus - Chordin - DAN - Decorin - Follistatin - Gremlin - Lefty - LTBP1 - Noggin - THBS1 |
| Coreceptors | BAMBI - Cripto |
| Other | SARA |
 |
This molecular or cell biology article is a stub. You can help Wikipedia by expanding it. |