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In the liturgical practice of the Orthodox Church, a Prokeimenon (Greek Προκειμενον, plural prokeimena; sometimes prokimenon/prokimena) is a psalm or canticle refrain sung responsorially at certain specified points of the Divine Liturgy or the Divine Office, usually to introduce a scripture reading.

It corresponds to the Gradual of the Roman Mass.

Prokeimena are not selected based on the personal preference of the priest, reader, or choir director. Rather, the Sunday and weekday prokeimena are taken from the Octoechos, using the particular tone of the day. Many feasts also have their own prokeimena.

The basic pattern of a prokeimenon is for the reader to chant a single verse of the psalm or canticle (often announcing the tone as well). This is repeated as a refrain by the choir, as the Reader chants additional verses (exactly how many depends on local practice). The Reader concludes the prokeimenon by chanting the first half of the first verse, and the choir then sings the second half. Alternately, if a feast is being celebrated together with a Sunday liturgy, a verse of that feast's prokeimenon will often replace the final verse of the Sunday prokeimenon.

The example given is the Sunday prokeimenon in Tone 8, assuming no additional feast. The verses are taken from Psalm 75 (Septuagint numbering).

Reader: "The prokeimenon is in the eighth tone: Pray and make your vows before the Lord our God!"

Choir: "Pray and make your vows before the Lord our God!"

Reader: "In Judah, God is known; His name is great in Israel!"

Choir: "Pray and make your vows before the Lord our God!"

Reader: "Pray and make your vows!"

Choir: "Before the Lord our God!"

In the Divine Liturgy, the prokeimenon always proceeds the Epistle reading, after the singing of the Trisagion.

At Vespers, the prokeimenon always follows the Entrance, whether or not there is an Old Testament reading to follow. Whenever there is a Gospel reading, whether at Matins or during a Moleben, it will be preceded by a prokeimenon. In Lent and Holy Week, at the Sixth Hour, a prokeimenon is also sung before and after a reading from the books of Isaiah or Jeremiah.