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The Patternist series (also known as the Patternmaster series) is a group of science fiction novels by Octavia E. Butler that detail a secret history continuing into the future from the Ancient Egyptian period to the far future, involving telepathic mind control and an extraterrestrial plague. A profile of Butler in Black Women in America notes that the themes of the series include "racial and gender-based animosity, the ethical implications of biological engineering, the question of what it means to be human, ethical and unethical uses of power, and how the assumption of power changes people." [1]

Butler's first published novel, 1976's Patternmaster, was the first book in this series to appear. From 1977 until 1984, she published four more Patternist novels: Mind of My Mind (1977), Survivor (1978), Wild Seed (1980) and Clay's Ark (1984). Until Butler began publishing the Xenogenesis trilogy in 1987, all but one of her published books were Patternist novels. (1979's Kindred was the exception.)

Butler later expressed a dislike for the novel Survivor, and declined to bring it back into print.

Chronologically, the series starts with the fourth novel published, Wild Seed. Set in the 17th and 18th centuries, the story involves the relationship between two immortals--Doro, a telepath who transfers his consciousness from one victim to another, and Anyanwu, a shape-shifter with perfect control over her body. They struggle to live together over generations as Doro attempts to create a new race through a selective breeding program.

The series' history continues with Mind of My Mind, in which Doro's breeding program has created a society of networked telepaths that he struggles to control.

Clay's Ark, the last book of the series to be published, deals with a colony of people who have been mutated by a disease that astronauts unwittingly brought back to Earth from outer space. The group struggles to keep itself isolated enough to keep the disease from spreading throughout humanity.

Survivor, the book in the series that Butler later disowned, depicts the Clay's Ark disease ravaging the Earth, and Doro's telepathic descendants asserting control over what remains of humanity. One group of regular humans decides to escape Earth to a new planet, where they struggle to co-exist with the species that already lives there.

Patternmaster, the first book to be published but the last in the series' internal chronology, depicts a distant future in which regular humans are dominated by the networked telepaths, who are themselves ruled by the most powerful telepath, known as the Patternmaster. The plot revolves around the aging of the current Patternmaster and the battle among other powerful telepaths to see who will become his successor. The descendants of the victims of the extraterrestrial disease, animalistic mutants known as Clayarks, make an appearance in the book.

• Salvaggio, Ruth. "Octavia Butler and the Black Science Fiction Heroine." Black American Literature Forum, Vol. 18, No. 2 (Summer 1984): 78-81.