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Nymphidius Sabinus (d. 68) was the son of an imperial freedwoman, Nymphidia. Some speculate that his father was a gladiator named Martianus, but there are also claims he was the illegitimate son of the former Roman Emperor Caligula.

After the Pisonian conspiracy against his alleged first cousin Nero in 65 A.D., executions created the opportunity for many to rise in Rome into positions of power. Among those to advance was Nymphidius, who became a colleague of Praetorian prefect Tigellinus in the Praetorian Guard after the latter's previous partner Faenius Rufus was put to death.

Nymphidius gradually consolidated some authority over the Praetorians, and his promise of material reward increased their willingness to declare for Galba during the provincial revolts of 68 A.D. which led to the senatorial rejection of Nero and to his suicide that same year.

Between the death of Nero and the arrival of Galba at Rome, Nymphidius wasted no time: he orchestrated the "resignation" of Tigellinus and stood as sole commander of the praetorian guard. Galba, however, appointed a replacement for Tigellinus, Cornelius Laco, and took several further steps to eliminate potential rivals (e.g., the murder of Lucius Clodius Macer in Africa Province), all of which must have made Nymphidius uneasy.

No longer content to help others to the throne, Nymphidius declared that he himself was a legitimate successor to Nero-- a claim which he supported with the dubious assertion that he was the illegitimate son of the former emperor Caligula. The Praetorians recognized that Galba's approach counted for more than Nymphidius' presence, and killed the would-be usurper before their new emperor arrived at Rome.

Nymphidius is significant not only because he played an instrumental part in the downfall of Nero, but also because he illustrates the heights to which even men of low birth could rise on their own initiative, as well as the tremendous importance of Praetorian loyalty for imperial succession in the turbulent Year of the Four Emperors which followed the death of Nero.