Nissl body

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Image of a Nissl-stained histological section through the rodent hippocampus showing various classes of neurons.
Image of a Nissl-stained histological section through the rodent hippocampus showing various classes of neurons.
Motor nerve cell from ventral horn of medulla spinalis of rabbit. The angular and spindle-shaped Nissl bodies are well shown.
Motor nerve cell from ventral horn of medulla spinalis of rabbit. The angular and spindle-shaped Nissl bodies are well shown.

A Nissl body (or Nissl granule or tigroid body) is a large granular body found in neurons. It was named after Franz Nissl, German neurologist (1860-1919).

Nissl bodies can be demonstrated by a method of selective staining developed by Nissl (Nissl staining), using an aniline stain to label extranuclear RNA granules. RNA stains blue with this method due to its basophilic (lat. "base-loving") properties.

These granules are rough endoplasmic reticulum (with ribosomes) and are the site of protein synthesis.

Nissl bodies show changes under various physiological conditions and in pathological conditions they may dissolve and disappear (karyolysis).

v • d • e
Histology: nervous tissue
Neurons (gray matter) soma, axon (axon hillock, axoplasm, axolemma, neurofibril/neurofilament), dendrite (Nissl body, dendritic spine, apical dendrite, basal dendrite)
types (bipolar, pseudounipolar, multipolar, pyramidal, Purkinje, granule)
Afferent nerve/Sensory nerve/Sensory neuron GSA, GVA, SSA, SVA, fibers (Ia, Ib or Golgi, II or Aβ, III or Aδ or fast pain, IV or C or slow pain)
Efferent nerve/Motor nerve/Motor neuron GSE, GVE, SVE, Upper motor neuron, Lower motor neuron (α motorneuron, γ motorneuron)
Synapses neuropil, synaptic vesicle, neuromuscular junction, electrical synapse - Interneuron (Renshaw)
Sensory receptors Free nerve ending, Meissner's corpuscle, Merkel nerve ending, Muscle spindle, Pacinian corpuscle, Ruffini ending, Olfactory receptor neuron, Photoreceptor cell, Hair cell, Taste bud
Glial cells astrocyte, oligodendrocyte, ependymal cells, microglia, radial glia
Myelination (white matter) Schwann cell, oligodendrocyte, nodes of Ranvier, internode, Schmidt-Lanterman incisures, neurolemma
Related connective tissues epineurium, perineurium, endoneurium, nerve fascicle, meninges
 This neuroscience article is a stub. You can help Wikipedia by expanding it.
Retrieved from "http://en.wikipedia.org/wiki/Nissl_body"
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