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Mission Valley is a wide valley trending east-west in San Diego, California, located by the San Diego River. Due to its massive size, it is divided into two neighborhoods: Mission Valley East located in the eastern region of San Diego, and Mission Valley West in the western region of the city.^[1]

Mission Valley serves as an important shopping and entertainment center for San Diego. Some newly-built condominiums and apartments can be found in the area as well.

Mission Valley stretches as far west as Interstate 5 and as far east as Interstate 15. The exact boundary where Mission Valley East and Mission Valley West are separated is at State Route 163.^{[2] [3]}

Mission Valley serves as a path for Interstate 8 and is crossed at its mouth by Interstate 5. Both I-8 and I-5 serve as the major east-west and north-south routes respectively, for San Diego. Interstate 15, Interstate 805, and State Route 163 serve Mission Valley as well.

To the east up Mission Valley is Mission San Diego de Alcala, for which the area is named. At the southwestern end is Presidio Park.

Three major shopping malls located in Mission Valley are Fashion Valley Mall (Mission Valley West), Hazard Center Mall (Mission Valley East) and Westfield Mission Valley (Mission Valley East). The frontage roads parallel to Interstate 8 from Presidio Park to Highway 163 are named Hotel Circle North and Hotel Circle South, for the many hotels and motels located on them. Other commercial developments can be found in the valley as well, including smaller shopping plazas, auto malls and vocational schools.

Qualcomm Stadium, home of the San Diego Chargers and the San Diego State University (SDSU) Aztecs football teams, is located in Mission Valley East near the I-8/I-15 interchange. Nearby, Dave & Buster's restaurant and entertainment venue is located at the intersection of the I-8 and I-805. At the outlet of Mission Valley is SeaWorld, Mission Bay, and many other San Diego attractions.