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McPhersonville is a place in eastern Hampton County, South Carolina, near the county's borders with Beaufort County and Jasper County. Once an important center of affluence and culture in colonial Prince William Parish (roughly analogous to modern-day Hampton County), McPhersonville is now little more than a marked location on a secondary road between Yemassee and Early Branch.

McPhersonville is located at 32° 41' 31" North, 80° 55' 09" West (32.6918437, -80.9192743) ^GR1. It is approximately 85 feet above sea level. The McPhersonville area is largely comprised of shady pine forests in sandy soil, which made it an attractive summer retreat for colonial plantation owners from the lower areas closer to the Atlantic coast, along with their extended families.

By the time of European colonization, Yemassee and Creek Indians from Florida had established trading posts, trails, burial grounds and ceremonial grounds throughout the pine woods and swampland surrounding McPhersonville. The first lasting English settlements in the McPhersonville area date to the 1670s, before the Carolinas were divided in 1729. In 1682, the Proprietary County of Colleton was established, within which were later created Parishes of St. Bartholomew's (1706), Prince William (1745), St. Peter's (1747) and St. Luke's (1767). In 1769, Beaufort District was created from the merger of three earlier parishes: St. Peter's, St. Luke's, and Prince William, the latter roughly corresponding to modern-day Hampton County.

McPhersonville proper was established by rice planters from along the Combahee and nearby rivers, who valued the inland area's cool winds, relatively low humidity and dense pine shade canopy. General James McPherson and his family were among the earliest residents; they were followed by the Drayton, McLeod, Pope, Mackey, Verdier, Brailsford, Martin, Palmer, McDougal, DeSaussure, Screven, Colcock, Hutson and Gregorie families. The Yemassee War of 1715 was largely fought in the areas around McPhersonville. It involved the Yemassee, Creeks and Choctaws, who rebelled against the unfair business practices of the region's white traders. Only a few score colonists were killed, but the loss of property was dramatic.

During the Revolutionary War, British troops occupied the plantation of Isaac McPherson (described as “a great Rebel, a man of property” in contemporary reports) in March, 1780, after unsuccessfully trying to chase down 50 American troops on horseback. During their stay the British engaged in what they thought was a skirmish with the enemy, but mistakenly attacked their own troops. The British left McPherson’s Plantation and marched to the crossing of the Saltketcher (now the Salkehatchie) River, where a bridge had stood before the beginning of the war. They were met by 80 American militiamen who tried to prevent their crossing. The British Light Infantry crossed the river below this spot and came up behind the Americans. A captain and 16 privates were bayoneted to death by the British.

Sherman in South Carolina: The burning of McPhersonville. Sketch by WIlliam Waud in Harper's Weekly, 1865

During the Civil War, McPhersonville was over-run early in the Carolinas Campaign by Sherman's forces. Only two pre-Civil War homes and one church escaped the Union Army's passage through the village. Stoney Creek Independent Presbyterian Chapel of Prince William Parish is the daughter chapel of old Stoney Creek Presbyterian Church, built in 1743 on the other side of the Pocotaligo River. The chapel was used as a hospital during the Civil War. It is on the National Register of Historic Places. Historic Prince William’s Episcopal Church, on the other hand, did not survive the Civil War; it was first built in 1832, as a summer place of worship by the congregation of Sheldon Church of Prince William’s Parish (now famous as "Old Sheldon" ruins). Sherman’s army destroyed it in 1865 following its use by the Confederates as a smallpox clinic. Prince William's strongest timbers were used to build bridges across the Combahee, and the Federals set fire to the rest. It was rebuilt in its present modest form in 1898.

The economic tumult of the post-Civil Area, compounded by the destruction of the local infrastructure by Sherman's troops began a long era of decline for McPhersonville, in terms of its commerce, summer occupancy and year-round population. The McPhersonville post office closed in the 1950s and the community is now served by Yemassee's branch office. There are no significant businesses in modern McPhersonville, though the area has experienced a small renaissance in the past 20 years as modern property owners and investors are drawn to the same favorable environmental conditions that lured the early settlers. Stoney Creek Independent Presbyterian Church is now administered by Stoney Creek Presbyterian Foundation, associated with First Presbyterian Church in Beaufort; it was used as a setting in the film Forrest Gump.

Coordinates: 32°41′31″N, 80°55′09″W