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In Greek mythology, Eriphyle, daughter of Talaus, was the mother of Alcmaeon and the wife of Amphiaraus. Eriphyle persuaded Amphiaraus to take part in the raid that initiated the mythic tale of the Seven Against Thebes, though she knew he would die. She had been persuaded by Polynices, who offered her the necklace of Harmonia for her assistance.

Amphiaraus asked his sons Alcmaeon and Amphilochus to avenge his death, and after Amphiaraus died, fulfilling the prophecy, Alcmaeon killed his mother. He was pursued by the Erinyes as he fled across Greece, eventually reaching the court of King Phegeus, who gave him his daughter in marriage. Exhausted, Alcmaeon asked an oracle how to assuage the Erinyes and was told that he needed to stop where the sun was not shining when he killed his mother. That was at the mouth of the river Achelous, which had been silted up. Achelous, the god of that river, offered him his daughter Callirhoe in marriage if Alcmaeon would retrieve the necklace and clothes that Eriphyle had worn when she persuaded Amphiaraus to take part in the battle. Alcmaeon had given these jewels to Phegeus, who had his sons kill Alcmaeon when he discovered Alcmaeon's plan.

Eriphyle is seen in Hell in Vergil's Aeneid, still bearing wounds inflicted by her son.

The necklace of Eriphyle was a gift to Cadmus when

"Zeus gave him to wife Harmonia, daughter of Aphrodite and Ares. And all the gods quitted the sky, and feasting in the Cadmea celebrated the marriage with hymns. Cadmus gave her a robe and the necklace wrought by Hephaestus, which some say was given to Cadmus by Hephaestus, but Pherecydes says that it was given by Europa, who had received it from Zeus." (Pseudo-Apollodorus, Bibliotheke iii.4.2)

A relic was being shown in Amathus in Cyprus, in the time of Pausanias (second century CE):

In Cyprus is a city Amathus, in which is an old sanctuary of Adonis and Aphrodite. Here they say is dedicated a necklace given originally to Harmonia, but called the necklace of Eriphyle, because it was the bribe she took to betray her husband. It was dedicated at Delphi by the sons of Phegeus (how they got it I have already related in my history of Arcadia), but it was carried off by the tyrants of Phocis." (Description of Greece ix.41.2)

The necklace that Pausanias was shown was of green stones with gold, which made him skeptical of it's being the one mentioned by Homer (Odyssey xi.327), for he noted other occasions in the Odyssey where necklaces made of gold and stones mention the stones.

• Pausanias, Description of Greece ix.41.2
• Biibliotheke iii.4.2