Dinoprostone

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Dinoprostone
Systematic (IUPAC) name
7-[3-hydroxy-2-(3-hydroxyoct-1-enyl)- 5-oxo-cyclopentyl] hept-5-enoic acid
Identifiers
CAS number 363-24-6
ATC code G02AD02
PubChem 9691
DrugBank APRD00927
Chemical data
Formula C20H32O5 
Mol. mass 352.465 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?
Legal status
Routes  ?

In medicine, dinoprostone, is a naturally occurring prostaglandin E2 (PGE2). It has important effects in labour and also stimulates osteoblasts to release factors which stimualtes bone resorption by osteoclasts.

It is sold under the trade name of Cervidil (by Forest Laboratories, Inc.), Prostin E2 (by Pfizer Inc.) and Propess (by Ferring Pharmaceuticals), as a vaginal suppository, to prepare the cervix for labour; it is used to induce labour.

The chemical name is (5Z,11(alpha),13E,15S)-11,15-Dihydroxy-9-oxo-prosta-5,13-dien-1-oic acid.

Like other prostaglandins, dinoprostone can be used as an abortifacient.

It works by binding and activating the prostaglandin E2 receptor.

v • d • e
Eicosanoids: prostaglandins
Endogenous/series 2 D2 - E2 (Dinoprostone) - H2 - I2 (Prostacyclin)
Prostaglandin analogues Alprostadil - Beraprost - Bimatoprost - Carboprost - Enprostil - Iloprost - Latanoprost - Misoprostol - Travoprost - Treprostinil
Retrieved from "http://en.wikipedia.org/wiki/Dinoprostone"
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