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Carbonic anhydrase inhibitors
From Wikipedia, the free encyclopedia
Carbonic anhydrase inhibitors are a class of pharmaceuticals which, as their name implies, act as an enzyme inhibitor upon carbonic anhydrase.
Acetazolamide is an inhibitor of carbonic anhydrase. It is used for glaucoma, epilepsy (rarely), benign intracranial hypertension, and altitude sickness. It can act as a mild diuretic by reducing NaCl and bicarbonate reabsorbtion in the proximal tubule. However, the distal segment partially compenates for the sodium loss, and the bicarbonaturia will produce a metabolic acidosis, further reducing the effect.
Methazolamide is also a carbonic anhydrase inhibitor. It is longer acting than acetazolamide and has less affect on the kidney[citation needed].
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Competitive inhibition - Uncompetitive inhibition - Non-competitive inhibition - Suicide inhibition - Mixed inhibition
Acetylcholinesterase inhibitors - Aromatase inhibitors - Carbonic anhydrase inhibitors - Kinase inhibitors - Monoamine oxidase inhibitors - Reverse transcriptase inhibitors - Phosphodiesterase inhibitors - Protease inhibitors