Bisacodyl

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Bisacodyl
Systematic (IUPAC) name
[4-[(4-acetyloxyphenyl)-pyridin-2-yl-methyl]phenyl] acetate
Identifiers
CAS number 603-50-9
ATC code A06AB02
PubChem 2391
Chemical data
Formula C22H19NO4 
Mol. mass 361.39
Pharmacokinetic data
Bioavailability 15%
Metabolism Hepatic CYP450
Half life 16 Hours
Excretion primarily in the faeces, systemically absorbed drug is excreted in the urine
Therapeutic considerations
Pregnancy cat.

C
Legal status

OTC
Routes Oral, Rectal

Bisacodyl is the International Nonproprietary Name of a compound that functions as a stimulant laxative. It is typically prescribed for relief of constipation and for the management of neurogenic bowel dysfunction. Bisacodyl is a diphenylmethane derivative and was first used as a laxative in 1953 due to its similarity to phenolphthalein [1].

Bisacodyl is sold under the trade names Dulcolax, Fleet, Alophen, Correctol, Carter's Little Pills as well as generically. It is usually sold as 5mg tablets, 10mg suppositories, or 5mg pediatric suppositories.

When biscodyl is administered orally, it is usually taken at bedtime, but when it is administered rectally, it is usually taken in the morning. This is due to the relatively long onset of the drug when taken orally (around 6-10 hours) compared to when it is taken rectally (around 15-60 minutes)


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