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Bcl-2-associated death promoter
From Wikipedia, the free encyclopedia
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BCL2-antagonist of cell death
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| Identifiers | |
| Symbol | BAD |
| HUGO | 936 |
| Entrez | 572 |
| OMIM | 603167 |
| RefSeq | NM_032989 |
| UniProt | Q92934 |
| Other data | |
| Locus | Chr. 11 q13.1 |
The Bcl-2-associated death promoter (BAD) protein is a pro-apoptotic member of the Bcl-2 gene family which is involved in initiating apoptosis. It does not contain a C-terminal transmembrane domain for outer mitochondrial membrane and nuclear envelope targeting, unlike most other members of the Bcl-2 family [1]. Pro-apoptotic activation of this protein occurs through phosphorylation[2]. After activation, it is able to form a heterodimer with anti-apoptotic proteins and prevent them from stopping apoptosis.
BAD is a member of the BH3-only family [3], a subfamily of the Bcl-2 family.
- ^ Sheau Yu Hsu, et al. (1997). "Interference of BAD (Bcl-xL/Bcl-2-Associated Death Promoter)-Induced Apoptosis in Mammalian Cells by 14–3-3 Isoforms and P11". Molecular Endocrinology 11 (12).
- ^ Entrez Gene entry for BAD. NCBI. Retrieved on [[2006-12-19]].
- ^ Adachi M. and Imai K. (2002). "The proapoptotic BH3-only protein BAD transduces cell death signals independently of its interaction with Bcl-2". Cell death and differentiation 9 (11).
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