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Anne de Mortimer (December 27, 1390 – September, 1411) was the daughter of Roger Mortimer, 4th Earl of March (1373-1398) and Alianore de Holland.

Her paternal grandparents were Edmund Mortimer, 3rd Earl of March and Philippa Plantagenet. Her maternal grandparents were Thomas Holland, 2nd Earl of Kent and Alice Fitzalan. Alice was a daughter of Richard FitzAlan, 10th Earl of Arundel and Eleanor of Lancaster.

Her paternal grandmother Philippa was the daughter of Lionel of Antwerp, 1st Duke of Clarence and Elizabeth de Burgh, 4th Countess of Ulster.

Anne's paternal great-grandfather Lionel of Antwerp was the second son of Edward III of England which placed Anne in line of succession for the throne of England. It was through her that her son Richard Plantagenet, 3rd Duke of York and the House of York claimed the throne.

• Lionel of Antwerp, 1st Duke of Clarence (1338–1368) [Second son of Edward III of England (1312-1377)]

• Philippa Plantagenet, 5th Countess of Ulster (1355–1382)

• Roger Mortimer, 4th Earl of March (1374–1398)

• Edmund Mortimer, 5th Earl of March (1391–1425)
• Roger Mortimer (died young c. 1409)
• Anne Mortimer (1390–1411)

• Richard Plantagenet, 3rd Duke of York (1411–1460)

In about 1406, she married Richard of Conisburgh, 3rd Earl of Cambridge, who was also descended from Edward III through a younger son Edmund of Langley, 1st Duke of York.

They had two children:

• Isabel Plantagenet
• Richard Plantagenet, 3rd Duke of York, who later laid claim to the throne, bringing about the Wars of the Roses

It is believed that Anne died giving birth to her son Richard in 1411.

In 1415 Anne's husband plotted with Henry "Hotspur" Percy to depose Henry V, Anne's cousin and the reigning king of England, and place her brother, Edmund Mortimer, 5th Earl of March on the throne. The Earl of March had been the heir presumptive of Richard II. In 1399 Richard was forced to abdicate in favour of Henry IV, and for the next few decades Mortimer served as a focal point for conspiracies aimed at removing Henry IV and his heirs from the throne.

The Earl of March was not involved in the plot which, despite its failure, successfully promoted the claim of Anne's descendants to the throne of England.