Amoxapine

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Amoxapine
Systematic (IUPAC) name
 ?
Identifiers
CAS number 14028-44-5
ATC code N06AA17
PubChem 2170
DrugBank APRD00142
Chemical data
Formula C17H16ClN3O 
Mol. mass 313.781
Pharmacokinetic data
Bioavailability  ?
Metabolism Hepatic (cytochrome P450 system)
Half life 8-10 hours (30 hours for major metabolites)
Excretion Renal
Therapeutic considerations
Pregnancy cat.

C(US)
Legal status

℞-only(US)
Routes Oral

Amoxapine (brand-names Asendin®, Asendis®, Defanyl®, Demolox®, Moxadil®) is a tetracyclic antidepressant of the dibenzoxazepine class. It is used in the treatment of depression, panic disorders and bipolar disorder.

Amoxapine is a strong reuptake inhibitor of norepinephrine and weak reuptake inhibitor of serotonin. One of its major metabolites, 7-hydroxyamoxapine, has a dopamine receptor blocking effect.

  • Mosby Year-Book, Inc. (1995). Physician's GenRx: The Complete Drug Reference (5th Ed.). Riverside, CT: Denniston Publishing Co.
  • Palfai, T. & Jankiewicz, H. (1997). Drugs and Human Behavior (2nd Ed.). Madison, WI: Brown & Benchmark.
  • Hedges, D. & Burchfield, C. (2006). Mind, Brain, and Drug: An Introduction to Psychopharmacology. Boston, MA: Pearson.


v • d • e
Antidepressants (ATC N06A)
Monoamine oxidase inhibitors (MAOI) Harmaline, Iproniazid, Isocarboxazid, Nialamide, Pargyline, Phenelzine, Selegiline, Toloxatone, Tranylcypromine
RIMAs: Brofaromine, Moclobemide
Dopamine reuptake inhibitor (DARI) Amineptine, Phenmetrazine, Vanoxerine
Norepinephrine-dopamine reuptake inhibitors (NDRI) Bupropion
Norepinephrine reuptake inhibitor (NRI) or (NARI) Atomoxetine, Maprotiline, Reboxetine, Viloxazine
Serotonin-norepinephrine reuptake inhibitor (SNRI) Duloxetine, Milnacipran, Nefazodone , Venlafaxine
Selective serotonin reuptake inhibitor (SSRI) Alaproclate, Citalopram, Escitalopram, Etoperidone, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Zimelidine
Selective serotonin reuptake enhancer (SSRE) Tianeptine
Noradrenergic and specific serotonergic antidepressant (NaSSA) Mirtazapine
Tricyclic antidepressants (TCA) Amitriptyline, Amoxapine, Butriptyline, Clomipramine, Desipramine, Dibenzepin, Dothiepin, Doxepin, Imipramine, Iprindole, Lofepramine, Melitracen, Nortriptyline, Opipramol, Protriptyline, Trimipramine
Tetracyclic antidepressants Maprotiline, Mianserin, Nefazodone, Trazodone


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